The primary goal of LLSA is to promote continuous learning by diplomates. The Medical Toxicology Subboard facilitates this learning by identifying a set of LLSA readings every other year to guide diplomates in self-study of recent Medical Toxicology literature. The readings are designed as study tools and should be read critically. They are not intended to be all-inclusive and are not meant to define the standard of care for the practicing medical toxicologist. The Medical Toxicology Subboard does not endorse a specific research finding or treatment modality--including off label use of medications-- by virtue of its being the subject of a selected LLSA reading. Likewise, the Subboard is mindful of the potential for real or perceived conflicts of interest in professional literature and makes a conscious effort to account for this in its LLSA reading selections. One criterion for choosing articles is that they be easily available from a variety of sources, such as common medical texts, libraries, and Internet websites. Whenever possible, ABEM provides online links to publishers’ websites or to the readings themselves. Accessibility and fees are at the discretion of the publisher, and are not related to ABEM in any way. All questions regarding fees or login information required to access the readings should be directed to the publisher or organization that published the article.
Assessment and Population Health
Gugelmann H, Perrone J, Nelson L. Windmills and pill mills: can PDMPs tilt the prescription drug epidemic? J Med Toxicol. 2012;8(4):387-86.
Geib AJ, Babu K, Ewald MB, Boyer EW. Adverse effects in children after unintentional buprenorphine exposure. Pediatrics. 2006;118(4):1746-51.
Rusyniak DE. Neurologic manifestations of chronic methamphetamine abuse. Psychiatr Clin North Am. 2013;36(2):261-75. Reprint from: Neurol Clin. 2011;29(3):641-55.
Principles of Toxicology
Hudak ML, Tan RC; Committee on Drugs; Committee on Fetus and Newborn; American Academy of Pediatrics. Neonatal drug withdrawal. Pediatrics. 2012;129(2):e540-60.
Daniulaityte R, Falck R, Calson RG. Illicit use of buprenorphine in a community sample of young adult non-medical users of pharmaceutical opioids. Drug Alcohol Depend. 2012;122(3):201-7.
de Lange DW, Sikma MA, Meulenbelt J. Extracorporeal membrane oxygenation in the treatment of poisoned patients. Clin Toxicol (Phila). 2013;51(5):385-93.
French D, Smollin C, Ruan W, Wong A, Drasner K, Wu AH. Partition constant and volume of distribution as predictors of clinical efficacy of lipid rescue for toxicological emergencies. Clin Toxicol (Phila). 2011;49(9):801-9.
Garlich FM, Goldfarb DS. Have advances in extracorporeal removal techniques changed the indications for their use in poisonings? Adv Chronic Kidney Dis. 2011;18(3):172-9.
Toxins and Toxicants
Eerenberg ES, Kamphuisen PW, Sijpkens MK, Meijers JC, Buller HR, Levi M. Reversal of rivaroxaban and dabigatran by prothrombin complex concentrate: a randomized, placebo-controlled, crossover study in healthy subjects. Circulation. 2011;124(14):1573-9.
Finkelstein Y, Aks SE, Hutson JR, et al. Colchicine poisoning: the dark side of an ancient drug. Clin Toxicol (Phila). 2010;48(5):407-14.
Hendrickson RG, McKeown NJ. Is maternal opioid use hazardous to breast-fed infants? Clin Toxicol (Phila). 2012;50(1):1-14.
Mazer M, Perrone J. Acetaminophen-induced nephrotoxicity: pathophysiology, clinical manifestations, and management. J Med Toxicol. 2008;4(1):2-6.
Pelclova Dk, Sklensky M, Janicek P, Lach K. Severe cobalt intoxication following hip replacement revision: clinical features and outcome. Clin Toxicol (Phila). 2012;50(4):262-5.
Prosser JM, Nelson LS. The toxicology of bath salts: a review of synthetic cathinones. J Med Toxicol. 2012;8(1):33-42.
Sharpe SJ, Rochette LM, Smith GA. Pediatric battery-related emergency department visits in the United States, 1990-2009. Pediatrics. 2012;129(6):1111-7.